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Issue 43, 2013
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A real-time colorimetric assay for label-free detection of microRNAs down to sub-femtomolar levels

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Abstract

A real-time colorimetric assay utilizing gold nanoparticle networks and a duplex-specific nuclease (DSN) for label-free detection of microRNAs is proposed. Excellent sensitivity and selectivity were accomplished through the engagement of the DSN and a cumulative signal amplification process.

Graphical abstract: A real-time colorimetric assay for label-free detection of microRNAs down to sub-femtomolar levels

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Article information


Submitted
01 Mar 2013
Accepted
08 Apr 2013
First published
22 Apr 2013

Chem. Commun., 2013,49, 4959-4961
Article type
Communication

A real-time colorimetric assay for label-free detection of microRNAs down to sub-femtomolar levels

W. Shen, H. Deng, Y. Ren and Z. Gao, Chem. Commun., 2013, 49, 4959
DOI: 10.1039/C3CC41565A

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