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Issue 26, 2013
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A catalytic multicomponent coupling reaction for the enantioselective synthesis of spiroacetals

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Abstract

The first multicomponent catalytic asymmetric synthesis of spiroacetals has been described. Hybrid molecules comprising a spiroacetal scaffold (a natural-product inspired scaffold) and an α-amino acid motif (a privileged fragment) are easily available through a gold phosphate-catalysed one-pot three component coupling reaction of alkynols, anilines and glyoxylic acid.

Graphical abstract: A catalytic multicomponent coupling reaction for the enantioselective synthesis of spiroacetals

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Publication details

The article was received on 06 Jan 2013, accepted on 12 Feb 2013 and first published on 13 Feb 2013


Article type: Communication
DOI: 10.1039/C3CC00118K
Chem. Commun., 2013,49, 2715-2717

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    A catalytic multicomponent coupling reaction for the enantioselective synthesis of spiroacetals

    L. Cala, A. Mendoza, F. J. Fañanás and F. Rodríguez, Chem. Commun., 2013, 49, 2715
    DOI: 10.1039/C3CC00118K

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