Issue 15, 2013
From the journal:

Chemical Communications

Palladium catalyzed cyclizations of oximeesters with 1,1-disubstituted alkenes: synthesis of α,α-disubstituted dihydropyrroles and studies towards an asymmetric protocol†

Adele Faulkner,a   James S. Scottb  and  John F. Bower*a  

* Corresponding authors

a School of Chemistry, University of Bristol, Bristol, UK
E-mail: john.bower@bris.ac.uk
Fax: +44 (0)117 927 7985

b AstraZeneca, Alderley Park, Macclesfield, Cheshire, UK

Abstract

We report efficient Pd-catalyzed cyclizations of oximeesters with 1,1-disubstituted alkenes as the basis of a general entry to α,α-disubstituted pyrrolidine derivatives. We also demonstrate that catalytic asymmetric variants of this chemistry are feasible by employing a suitable chiral ligand.

Graphical abstract: Palladium catalyzed cyclizations of oximeesters with 1,1-disubstituted alkenes: synthesis of α,α-disubstituted dihydropyrroles and studies towards an asymmetric protocol

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Article information

DOI
https://doi.org/10.1039/C2CC38944D
Article type
Communication
Submitted
14 Dec 2012
Accepted
04 Jan 2013
First published
04 Jan 2013
This article is Open Access
Creative Commons BY license

Chem. Commun., 2013,49, 1521-1523

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Palladium catalyzed cyclizations of oximeesters with 1,1-disubstituted alkenes: synthesis of α,α-disubstituted dihydropyrroles and studies towards an asymmetric protocol

A. Faulkner, J. S. Scott and J. F. Bower, Chem. Commun., 2013, 49, 1521 DOI: 10.1039/C2CC38944D

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