Jump to main content
Jump to site search

Issue 11, 2013
Previous Article Next Article

Enhanced drug delivery to hepatocellular carcinoma with a galactosylated core–shell polyphosphoester nanogel

Author affiliations

Abstract

Effective systemic therapy is often necessary to treat hepatocellular carcinoma (HCC). We synthesized a Gal-PPE nanogel consisting of a cross-linked polyphosphate core and galactosylated poly(ethylene glycol) arms for enhanced doxorubicin delivery to diethylnitrosamine-induced HCC in rats. The Gal-PPE nanogel exhibited high affinity to HepG2 cells in vitro, mediated by the asialoglycoprotein receptor. In vivo studies revealed that the Gal-PPE nanogel was taken up more efficiently by hepatocytes, in contrast to m-PPE nanogel. Consequently, doxorubicin delivery with Gal-PPE significantly inhibited the progress of HCC, reducing neoplastic liver nodules and prolonging the survival time of HCC rats more significantly. These results demonstrate the potential of Gal-PPE as a nanocarrier for improved HCC chemotherapy.

Graphical abstract: Enhanced drug delivery to hepatocellular carcinoma with a galactosylated core–shell polyphosphoester nanogel

Back to tab navigation

Supplementary files

Article information


Submitted
16 Apr 2013
Accepted
06 Jun 2013
First published
17 Jul 2013

Biomater. Sci., 2013,1, 1143-1150
Article type
Paper

Enhanced drug delivery to hepatocellular carcinoma with a galactosylated core–shell polyphosphoester nanogel

J. Wu, T. Sun, X. Yang, J. Zhu, X. Du, Y. Yao, M. Xiong, H. Wang, Y. Wang and J. Wang, Biomater. Sci., 2013, 1, 1143
DOI: 10.1039/C3BM60099H

Social activity

Search articles by author

Spotlight

Advertisements