Enhanced intracellular drug delivery of pH-sensitive doxorubicin/poly(ethylene glycol)-block-poly(4-vinylbenzylphosphonate) nanoparticles in multi-drug resistant human epidermoid KB carcinoma cells†
Abstract
A pH-sensitive
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* Corresponding authors
a
Department of Materials Science, Graduate School of Pure and Applied Sciences, University of Tsukuba, Tennoudai 1-1-1, Tsukuba, Ibaraki, Japan
E-mail:
yukio@nagalabo.jp
Fax: (+81)-29-853-5749
Tel: (+81)-29-853-5749
b Department of Molecular Oncology, Graduate School of Medical and Dental Sciences, Kagoshima University, 8-35-1 Sakuragaoka, Kagoshima 890-8520, Japan
c Department of Medical Oncology, Institute of Health Biosciences, The University of Tokushima Graduate School, 3-18-15 Kuramoto-cho, Tokushima 770-8503, Japan
d Master’s School of Medical Sciences, Graduate School of Comprehensive Human Sciences, University of Tsukuba, Tennoudai 1-1-1 Tsukuba, Ibaraki 305-8573, Japan
e Satellite Laboratory, International Center for Materials Nanoarchitectonics (MANA), National Institute for Materials Science (NIMS), University of Tsukuba, Tennoudai 1-1-1, Tsukuba, Ibaraki, Japan
A pH-sensitive
M. Kamimura, T. Furukawa, S. Akiyama and Y. Nagasaki, Biomater. Sci., 2013, 1, 361 DOI: 10.1039/C2BM00156J
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