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Issue 2, 2013
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Mesoporous silicananoparticles for the design of smart delivery nanodevices

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Abstract

Mesoporous silica nanoparticles (MSNPs) are receiving growing attention by the scientific community for their groundbreaking potential in nanomedicine. It is possible to load huge amounts of cargo into the mesopore voids and capping the pore entrances with different nanogates. Different internal or external stimuli can provoke the nanocap removal and trigger the departure of the cargo, which permits the design of stimuli-responsive drug delivery nanodevices. It is also feasible to combine the multifunctionality of MSNPs with the wide range of applications of magnetic nanoparticles (mNPs), giving rise to advanced smart nanosystems whose features and functionality can be tailored attending to specific clinical needs. This review describes the possible combinations of MSNPs, stimuli-responsive nanocaps and mNPs and the current scientific challenges aimed at accelerating the progression from bench to bedside.

Graphical abstract: Mesoporous silica nanoparticles for the design of smart delivery nanodevices

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Article information


Submitted
04 Jul 2012
Accepted
16 Aug 2012
First published
21 Sep 2012

Biomater. Sci., 2013,1, 114-134
Article type
Review Article

Mesoporous silica nanoparticles for the design of smart delivery nanodevices

M. Colilla, B. González and M. Vallet-Regí, Biomater. Sci., 2013, 1, 114
DOI: 10.1039/C2BM00085G

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