Issue 9, 2013
From the journal:

Biomaterials Science

Dual-responsive drug release from oligonucleotide-capped mesoporous silica nanoparticles†

Xing Ma,a   Onn Shaun Onga  and  Yanli Zhao*ab  

* Corresponding authors

a School of Materials Science and Engineering, Nanyang Technological University, 50 Nanyang Avenue, Singapore 639798
E-mail: zhaoyanli@ntu.edu.sg

b Division of Chemistry and Biological Chemistry, School of Physical and Mathematical Sciences, Nanyang Technological University, 21 Nanyang Link, Singapore 637371

Abstract

Mesoporous silica nanoparticles (MSNPs) are functionalized with 15-mer single-stranded DNA (ssDNA). After loading of doxorubicin, functionalized MSNPs are capped with 33-mer complementary ssDNA through the formation of double-stranded DNA. Encapsulated doxorubicin could be released by either thermal-triggered denaturization of the DNA capping chains or redox-induced disulfide bond cleavage. An in vitro study shows successful delivery of doxorubicin into HeLa cells.

Graphical abstract: Dual-responsive drug release from oligonucleotide-capped mesoporous silica nanoparticles

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Article information

DOI
https://doi.org/10.1039/C3BM60090D
Article type
Communication
Submitted
09 Apr 2013
Accepted
16 May 2013
First published
10 Jun 2013

Biomater. Sci., 2013,1, 912-917

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Dual-responsive drug release from oligonucleotide-capped mesoporous silica nanoparticles

X. Ma, O. S. Ong and Y. Zhao, Biomater. Sci., 2013, 1, 912 DOI: 10.1039/C3BM60090D

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