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Issue 9, 2013
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Dual-responsive drug release from oligonucleotide-capped mesoporous silica nanoparticles

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Abstract

Mesoporous silica nanoparticles (MSNPs) are functionalized with 15-mer single-stranded DNA (ssDNA). After loading of doxorubicin, functionalized MSNPs are capped with 33-mer complementary ssDNA through the formation of double-stranded DNA. Encapsulated doxorubicin could be released by either thermal-triggered denaturization of the DNA capping chains or redox-induced disulfide bond cleavage. An in vitro study shows successful delivery of doxorubicin into HeLa cells.

Graphical abstract: Dual-responsive drug release from oligonucleotide-capped mesoporous silica nanoparticles

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Article information


Submitted
09 Apr 2013
Accepted
16 May 2013
First published
10 Jun 2013

Biomater. Sci., 2013,1, 912-917
Article type
Communication

Dual-responsive drug release from oligonucleotide-capped mesoporous silica nanoparticles

X. Ma, O. S. Ong and Y. Zhao, Biomater. Sci., 2013, 1, 912
DOI: 10.1039/C3BM60090D

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