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Issue 14, 2013
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Blood plasma surface-enhanced Raman spectroscopy for non-invasive optical detection of cervical cancer†

Shangyuan Feng,‡a   Duo Lin,‡b   Juqiang Lin,a   Buhong Li,a   Zufang Huang,a   Guannan Chen,a   Wei Zhang,c   Lan Wang,a   Jianji Pan,c   Rong Chena  and  Haishan Zeng*ad  
Author affiliations

* Corresponding authors

a Key Laboratory of OptoElectronic Science and Technology for Medicine, Ministry of Education, Fujian Normal University, Fuzhou 350007, China
E-mail: hzeng@bccrc.ca
Fax: +86 591 83465373
Tel: +86 59183489919

b College of Integrated Traditional Chinese and Western Medicine, Fujian University of Traditional Chinese Medicine, Fuzhou, China

c Fujian Provincial Tumor Hospital, Fuzhou 350001, China

d Imaging Unit – Integrative Oncology Department, British Columbia Cancer Agency Research Centre, Vancouver, B.C., Canada

Abstract

Based on blood plasma surface-enhanced Raman spectroscopy (SERS) analysis, a simple and label-free blood test for non-invasive cervical cancer detection is presented in this paper. SERS measurements were performed on blood plasma samples from 60 cervical cancer patients and 50 healthy volunteers. Both the empirical approach and multivariate statistical techniques, including principal component analysis (PCA) and linear discriminant analysis (LDA), were employed to analyze and differentiate the obtained blood plasma SERS spectra. The empirical diagnostic algorithm based on the integration area of the SERS spectral bands (1310–1430 and 1560–1700 cm−1) achieved a diagnostic sensitivity of 70% and 83.3%, and a specificity of 76% and 78%, respectively, whereas the diagnostic algorithms based on PCA-LDA yielded a better diagnostic sensitivity of 96.7% and a specificity of 92% for separating cancerous samples from normal samples. This exploratory work demonstrates that a silver nanoparticle based SERS plasma analysis technique in conjunction with PCA-LDA has potential for improving cervical cancer detection and screening.

Graphical abstract: Blood plasma surface-enhanced Raman spectroscopy for non-invasive optical detection of cervical cancer

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Publication details

The article was received on 21 Dec 2012, accepted on 07 Mar 2013 and first published on 07 Mar 2013


Article type: Paper
DOI: 10.1039/C3AN36890D
Analyst, 2013,138, 3967-3974

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    Blood plasma surface-enhanced Raman spectroscopy for non-invasive optical detection of cervical cancer

    S. Feng, D. Lin, J. Lin, B. Li, Z. Huang, G. Chen, W. Zhang, L. Wang, J. Pan, R. Chen and H. Zeng, Analyst, 2013, 138, 3967
    DOI: 10.1039/C3AN36890D

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