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Issue 21, 2013
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Analysis of free fractions for chiral drugs using ultrafast extraction and multi-dimensional high-performance affinity chromatography

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Abstract

A multi-dimensional chromatographic approach was developed to measure the free fractions of drug enantiomers in samples that also contained a binding protein or serum. This method, which combined ultrafast affinity extraction with a chiral stationary phase, was demonstrated using the drug warfarin and the protein human serum albumin.

Graphical abstract: Analysis of free fractions for chiral drugs using ultrafast extraction and multi-dimensional high-performance affinity chromatography

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Article information


Submitted
09 Jul 2013
Accepted
21 Aug 2013
First published
21 Aug 2013

Analyst, 2013,138, 6262-6265
Article type
Communication

Analysis of free fractions for chiral drugs using ultrafast extraction and multi-dimensional high-performance affinity chromatography

X. Zheng, M. J. Yoo and D. S. Hage, Analyst, 2013, 138, 6262
DOI: 10.1039/C3AN01315D

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