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Issue 21, 2013
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A chemical quenching- and physical blocking-based method to minimize process-mediated aggregation of antibody-crosslinked nanoparticles for imaging application

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Abstract

Critical limitation of nanoparticles (NP) is their aggregation after functionalisation and antibody cross-linking. We analysed the cause of this aggregation with respect to functionalities (carboxyls and amines) on the NP surface. We have devised a low cost novel method to reduce such aggregations during protein cross-linking and validated it by probing the platelet surface with platelet surface-specific anti-CD41 antibody conjugated NPs.

Graphical abstract: A chemical quenching- and physical blocking-based method to minimize process-mediated aggregation of antibody-crosslinked nanoparticles for imaging application

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Article information


Submitted
05 Jul 2013
Accepted
12 Aug 2013
First published
12 Aug 2013

Analyst, 2013,138, 6277-6281
Article type
Communication

A chemical quenching- and physical blocking-based method to minimize process-mediated aggregation of antibody-crosslinked nanoparticles for imaging application

C. K. Dixit, S. Roy, C. Byrne, R. O'Kennedy and C. McDonagh, Analyst, 2013, 138, 6277
DOI: 10.1039/C3AN01294H

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