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Issue 21, 2013
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A smart T1-weighted MRI contrast agent for uranyl cations based on a DNAzyme–gadolinium conjugate

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Abstract

Rational design of smart MRI contrast agents with high specificity for metal ions remains a challenge. Here, we report a general strategy for the design of smart MRI contrast agents for detecting metal ions based on conjugation of a DNAzyme with a gadolinium complex. The 39E DNAzyme, which has high selectivity for UO22+, was conjugated to Gd(III)–DOTA and streptavidin. The binding of UO22+ to its 39E DNAzyme resulted in the dissociation of Gd(III)–DOTA from the large streptavidin, leading to a decrease of the T1 correlation time, and a change in the MRI signal.

Graphical abstract: A smart T1-weighted MRI contrast agent for uranyl cations based on a DNAzyme–gadolinium conjugate

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Article information


Submitted
14 Jun 2013
Accepted
10 Aug 2013
First published
12 Aug 2013

Analyst, 2013,138, 6266-6269
Article type
Communication

A smart T1-weighted MRI contrast agent for uranyl cations based on a DNAzyme–gadolinium conjugate

W. Xu, H. Xing and Y. Lu, Analyst, 2013, 138, 6266
DOI: 10.1039/C3AN01182H

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