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Issue 4, 2013
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Nanoparticle-based immunoassays in the biomedical field

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Abstract

Recent research has looked to develop innovative, powerful and novel biofunctionalized nanoparticles, controlling and tailoring their properties in a very predictable manner to meet the needs of clinic immunoassays in the biomedical field. This minireview briefly summarizes recent advances covering the last 3 years, exploiting nanoparticle-based electrochemical, optical, mass-sensitive, colorimetric and immunodipstick assays. The enormous signal enhancement associated with the use of nanoparticles and formation of nanoparticle–antibody–antigen assemblies provide the basis for sensitive detection of disease-related proteins or biomarkers. Rather than being exhaustive, this minireview focuses on selected examples to illustrate novel concepts and promising applications. Finally, a small amount of speculation of possible future developments in nanoparticle-based immunoassays is provided.

Graphical abstract: Nanoparticle-based immunoassays in the biomedical field

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Article information


Submitted
17 Oct 2012
Accepted
11 Dec 2012
First published
12 Dec 2012

Analyst, 2013,138, 981-990
Article type
Minireview

Nanoparticle-based immunoassays in the biomedical field

D. Tang, Y. Cui and G. Chen, Analyst, 2013, 138, 981
DOI: 10.1039/C2AN36500F

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