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Issue 2, 2013
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3D confocal Raman imaging of endothelial cells and vascular wall: perspectives in analytical spectroscopy of biomedical research

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Abstract

Raman imaging was used to illustrate heterogeneity of a single endothelial cell and the vascular wall sample. The spectral analysis allowed for exploring the complexity of the studied systems in three dimensions and defining the size, volume, shape and biochemical composition of cellular organelles. The ability to construct the 3D maps by a method that does not disrupt the spatial integrity of the cell provided a unique insight into biochemical architecture and cellular processes of endothelium and vascular wall. 3D Raman imaging may be considered as a new trend in analytical spectroscopy to be applied in biomedical research. This method has a potential to be used for medical imaging and diagnostic purposes together with other, already established, imaging techniques.

Graphical abstract: 3D confocal Raman imaging of endothelial cells and vascular wall: perspectives in analytical spectroscopy of biomedical research

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Supplementary files

Article information


Submitted
30 Aug 2012
Accepted
30 Oct 2012
First published
31 Oct 2012

Analyst, 2013,138, 603-610
Article type
Paper

3D confocal Raman imaging of endothelial cells and vascular wall: perspectives in analytical spectroscopy of biomedical research

K. Majzner, A. Kaczor, N. Kachamakova-Trojanowska, A. Fedorowicz, S. Chlopicki and M. Baranska, Analyst, 2013, 138, 603
DOI: 10.1039/C2AN36222H

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