Estimation of human equivalent exposure from rat inhalation toxicity study of silver nanoparticles using multi-path particle dosimetry model
Abstract
Respiratory tract dosimetry is a useful tool to estimate the exposure concentrations of an inhaled substance that will produce the same result at a target site of the respiratory tract in both rats and humans. Thus, to enable the results of animal inhalation studies to be extrapolated to human equivalent exposure levels, the MPPD (multi-path particle dosimetry) model was used to estimate the differences in the respiratory dosimetry of rats and humans. In our previous study, when animals were subchronically exposed to