Jump to main content
Jump to site search

Issue 1, 2012
Previous Article Next Article

Mechanisms and modifiers of methylmercury-induced neurotoxicity

Author affiliations

Abstract

The neurotoxic consequences of methylmercury (MeHg) exposure have long been known, however a complete understanding of the mechanisms underlying this toxicity is elusive. Recent epidemiological and experimental studies have provided mechanistic insights into the contribution of genetic and environmental factors that interact with MeHg to modify toxicity. This review will outline cellular processes directly and indirectly affected by MeHg, including oxidative stress, cellular signaling and gene expression, and discuss epigenetic modifications, genetic polymorphisms and gene–environment interactions capable of modifying MeHg neurotoxicity.

Graphical abstract: Mechanisms and modifiers of methylmercury-induced neurotoxicity

Back to tab navigation

Publication details

The article was received on 30 Jan 2012, accepted on 02 May 2012 and first published on 02 May 2012


Article type: Review Article
DOI: 10.1039/C2TX20010D
Citation: Toxicol. Res., 2012,1, 32-38

  •   Request permissions

    Mechanisms and modifiers of methylmercury-induced neurotoxicity

    S. J. B. Fretham, S. Caito, E. J. Martinez-Finley and M. Aschner, Toxicol. Res., 2012, 1, 32
    DOI: 10.1039/C2TX20010D

Search articles by author

Spotlight

Advertisements