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Issue 1, 2013
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pH-triggered self-assembly of biocompatible histamine-functionalized triblock copolymers

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Abstract

Histamine functionalized poly(allyl glycidyl ether)-b-poly(ethylene glycol)-b-poly(allyl glycidyl ether) (PAGE-PEO-PAGE) triblock copolymers represent a new class of physically cross-linked, pH-responsive hydrogels with significant potential for biomedical applications. These telechelic triblock copolymers exhibited abrupt and reversible hydrogelation above pH 7.0 due to a hydrophilic/hydrophobic transition of the histamine units to form a network of hydrophobic domains bridged by a hydrophilic PEO matrix. These hydrophobic domains displayed improved ordering upon increasing pH and self-assembled into a body centered cubic lattice at pH 8.0, while at lower concentrations formed well-defined micelles. Significantly, all materials were found to be non-toxic when evaluated on three different cell lines and suggests a range of medical and biomedical applications.

Graphical abstract: pH-triggered self-assembly of biocompatible histamine-functionalized triblock copolymers

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Article information


Submitted
29 Aug 2012
Accepted
03 Oct 2012
First published
15 Oct 2012

Soft Matter, 2013,9, 82-89
Article type
Paper

pH-triggered self-assembly of biocompatible histamine-functionalized triblock copolymers

P. Lundberg, N. A. Lynd, Y. Zhang, X. Zeng, D. V. Krogstad, T. Paffen, M. Malkoch, A. M. Nyström and C. J. Hawker, Soft Matter, 2013, 9, 82
DOI: 10.1039/C2SM26996A

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