Jump to main content
Jump to site search

Issue 41, 2012
Previous Article Next Article

Microfluidic systems for single DNA dynamics

Author affiliations


Recent advances in microfluidics have enabled the molecular-level study of polymer dynamics using single DNA chains. Single polymer studies based on fluorescence microscopy allow for the direct observation of non-equilibrium polymer conformations and dynamical phenomena such as diffusion, relaxation, and molecular stretching pathways in flow. Microfluidic devices have enabled the precise control of model flow fields to study the non-equilibrium dynamics of soft materials, with device geometries including curved channels, cross slots, and microfabricated obstacles and structures. This review explores recent microfluidic systems that have advanced the study of single polymer dynamics, while identifying new directions in the field that will further elucidate the relationship between polymer microstructure and bulk rheological properties.

Graphical abstract: Microfluidic systems for single DNA dynamics

Back to tab navigation

Publication details

The article was received on 03 May 2012, accepted on 14 Jun 2012 and first published on 03 Jul 2012

Article type: Review Article
DOI: 10.1039/C2SM26036K
Soft Matter, 2012,8, 10560-10572

  •   Request permissions

    Microfluidic systems for single DNA dynamics

    D. J. Mai, C. Brockman and C. M. Schroeder, Soft Matter, 2012, 8, 10560
    DOI: 10.1039/C2SM26036K

Search articles by author