Issue 21, 2012
From the journal:

Soft Matter

Organic–inorganic nanovesicles for doxorubicin storage and release†

Siu Ling Leung,a   Zhengbao Zha,ab   Weibing Teng,a   Celine Cohn,c   Zhifei Dai*b  and  Xiaoyi Wu*ac  

* Corresponding authors

a Department of Aerospace and Mechanical Engineering, University of Arizona, Tucson, AZ 85721, USA
E-mail: xwu@email.arizona.edu
Fax: +1-00-520-621-8191
Tel: +1-00-520-626-5854

b Department of Biomedical Engineering, College of Engineering, Peking University, Beijing 100871, People's Republic of China
E-mail: zhfdai@coe.pku.edu.cn

c Biomedical Engineering and Bio5 Institute, University of Arizona, Tucson, AZ 85721, USA

Abstract

The potential of organic–inorganic liposomal cerasomes to store and release doxorubicin (DOX) is investigated. Specifically, cerasomes display sustained DOX release in serum-enriched cell culture medium but minimal drug leakage in deionized water. As revealed by a physics-based model, the medium-sensitive DOX release/leakage is attributed to serum-mediated dissociation of DOX molecules. DOX-loaded cerasomes effectively inhibit the proliferation of human prostate cancer DU145 cells. Furthermore, the kinetics of cerasome uptake/internalization and DOX release correlates well with the time scale for DOX-loaded cerasomes to inhibit the proliferation of the DU145 cells.

Graphical abstract: Organic–inorganic nanovesicles for doxorubicin storage and release

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Article information

DOI
https://doi.org/10.1039/C2SM07452D
Article type
Paper
Submitted
23 Dec 2011
Accepted
05 Mar 2012
First published
21 Mar 2012

Soft Matter, 2012,8, 5756-5764

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Organic–inorganic nanovesicles for doxorubicin storage and release

S. L. Leung, Z. Zha, W. Teng, C. Cohn, Z. Dai and X. Wu, Soft Matter, 2012, 8, 5756 DOI: 10.1039/C2SM07452D

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