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Issue 7, 2012
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Controlling the temperature sensitivity of DNA-mediated colloidal interactions through competing linkages

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Abstract

We propose a new strategy to improve the self-assembly properties of DNA-functionalised colloids. The problem that we address is that DNA-functionalised colloids typically crystallize in a narrow temperature window, if at all. The underlying reason is the extreme sensitivity of DNA-mediated interactions to temperature or other physical control parameters. We propose to widen the window for colloidal crystallization by exploiting the competition between DNA linkages with different nucleotide sequences, which results in a temperature-dependent switching of the dominant bond type. Following such a strategy, we can decrease the temperature dependence of DNA-mediated self assembly to make systems that can crystallize in a wider temperature window than is possible with existing systems of DNA functionalised colloids. We report Monte Carlo simulations that show that the proposed strategy can indeed work in practice for real systems and specific, designable DNA sequences. Depending on the length ratio of the different DNA constructs, we find that the bond switching is either energetically driven (equal length or ‘symmetric’ DNA) or controlled by a combinatorial entropy gain (‘asymmetric’ DNA), which results from the large number of possible binding partners for each DNA strand. We provide specific suggestions for the DNA sequences with which these effects can be achieved experimentally.

Graphical abstract: Controlling the temperature sensitivity of DNA-mediated colloidal interactions through competing linkages

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Article information


Submitted
26 Aug 2011
Accepted
02 Dec 2011
First published
06 Jan 2012

Soft Matter, 2012,8, 2213-2221
Article type
Paper

Controlling the temperature sensitivity of DNA-mediated colloidal interactions through competing linkages

B. M. Mognetti, M. E. Leunissen and D. Frenkel, Soft Matter, 2012, 8, 2213
DOI: 10.1039/C2SM06635A

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