Issue 4, 2012

Fmoc-diphenylalanine hydrogels: understanding the variability in reported mechanical properties

Abstract

Fmoc-diphenylalanine (FmocFF or FmocPhePhe) is an important low molecular weight hydrogelator. Gelation can be induced by either lowering the pH of an aqueous solution of FmocFF or by the addition of water to a solution of FmocFF in a solvent such as DMSO. Despite the volume of literature on FmocFF, the mechanical properties reported for the gels vary significantly over four orders of magnitude and the origins of this variability is unclear. Here, we study systematically the mechanical properties of FmocFF gels prepared with different protocols. We demonstrate that the final pH of the gels is the principal determinant of the mechanical properties independently of the method of gel formation. We also show that additional variability arises from experimental factors such as the fraction of DMSO or the nature of the buffers used in selected systems.

Graphical abstract: Fmoc-diphenylalanine hydrogels: understanding the variability in reported mechanical properties

Supplementary files

Article information

Article type
Paper
Submitted
10 Oct 2011
Accepted
15 Nov 2011
First published
28 Nov 2011

Soft Matter, 2012,8, 1168-1174

Fmoc-diphenylalanine hydrogels: understanding the variability in reported mechanical properties

J. Raeburn, G. Pont, L. Chen, Y. Cesbron, R. Lévy and D. J. Adams, Soft Matter, 2012, 8, 1168 DOI: 10.1039/C1SM06929B

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