Issue 11, 2012
From the journal:

Chemical Science

Copper-catalyzed decarboxylative C–N coupling for N-arylation†

Yun Zhang,a   Sejal Patel*a  and  Nello Mainolfi*a  

* Corresponding authors

a Novartis Institutes for BioMedical Research Inc., Global Discovery Chemistry (GDC), Cambridge, MA 02139, USA
E-mail: nello.mainolfi@novartis.com, sejal.patel@novartis.com
Tel: +1 617 8717394

Abstract

A novel approach for N-arylation utilizing aryl carboxylic acids as stable, inexpensive and widely available arylating reagents was developed. Employing a simple copper(II)–phenanthroline catalyst system, several benzoic acids bearing suitable ortho-substitutions undergo decarboxylative C–N cross-coupling effectively with various N-nucleophiles.

Graphical abstract: Copper-catalyzed decarboxylative C–N coupling for N-arylation

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Article information

DOI
https://doi.org/10.1039/C2SC20606D
Article type
Edge Article
Submitted
14 May 2012
Accepted
14 Jul 2012
First published
16 Jul 2012

Chem. Sci., 2012,3, 3196-3199

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Copper-catalyzed decarboxylative C–N coupling for N-arylation

Y. Zhang, S. Patel and N. Mainolfi, Chem. Sci., 2012, 3, 3196 DOI: 10.1039/C2SC20606D

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