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Issue 6, 2012
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Hindered biaryls by C–H coupling: bisoxazoline-Pd catalysis leading to enantioselective C–H coupling

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Abstract

A new Pd-catalyzed C–H/C–B coupling of sterically hindered heteroarenes and arylboronic acids has been identified. The newly established Pd(OAc)2/bisoxazoline/TEMPO system not only enables the synthesis of sterically hindered heterobiaryls but also offers an opportunity for enantioselective biaryl coupling through C–H functionalization.

Graphical abstract: Hindered biaryls by C–H coupling: bisoxazoline-Pd catalysis leading to enantioselective C–H coupling

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Article information


Submitted
06 Mar 2012
Accepted
20 Mar 2012
First published
21 Mar 2012

Chem. Sci., 2012,3, 2165-2169
Article type
Edge Article

Hindered biaryls by C–H coupling: bisoxazoline-Pd catalysis leading to enantioselective C–H coupling

K. Yamaguchi, J. Yamaguchi, A. Studer and K. Itami, Chem. Sci., 2012, 3, 2165
DOI: 10.1039/C2SC20277H

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