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Issue 3, 2012
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Synergistic catalysis: A powerful synthetic strategy for new reaction development

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Abstract

Synergistic catalysis is a synthetic strategy wherein both the nucleophile and the electrophile are simultaneously activated by two separate and distinct catalysts to afford a single chemical transformation. This powerful catalysis strategy leads to several benefits, specifically synergistic catalysis can (i) introduce new, previously unattainable chemical transformations, (ii) improve the efficiency of existing transformations, and (iii) create or improve catalytic enantioselectivity where stereocontrol was previously absent or challenging. This perspective aims to highlight these benefits using many of the successful examples of synergistic catalysis found in the literature.

Graphical abstract: Synergistic catalysis: A powerful synthetic strategy for new reaction development

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Article information


Submitted
11 Nov 2011
Accepted
02 Dec 2011
First published
25 Jan 2012

Chem. Sci., 2012,3, 633-658
Article type
Perspective

Synergistic catalysis: A powerful synthetic strategy for new reaction development

A. E. Allen and D. W. C. MacMillan, Chem. Sci., 2012, 3, 633
DOI: 10.1039/C2SC00907B

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