Jump to main content
Jump to site search

Issue 2, 2012
Previous Article Next Article

The all-photochemical synthesis of an OGP(10–14) precursor

Author affiliations

Abstract

An all-photochemical synthesis of OGP(10–14), the biologically active part of an osteogenic growth peptide, was performed. This required the preparation of photochemically activable amino acids containing a 5,7-dinitroindoline derivative on the C-terminus and a photolabile Ddz protecting group on the N-terminus. The photochemical acyl transfer from the dinitroindoline to an incoming nucleophilic amino group, which creates the amide bond, requires an irradiation wavelength of 385 nm. The deprotection of the Ddz group requires a shorter wavelength (300 nm), thus making both successive processes compatible.

Graphical abstract: The all-photochemical synthesis of an OGP(10–14) precursor

Back to tab navigation

Supplementary files

Publication details

The article was received on 20 Sep 2011, accepted on 05 Oct 2011 and first published on 06 Oct 2011


Article type: Edge Article
DOI: 10.1039/C1SC00700A
Chem. Sci., 2012,3, 405-406

  •   Request permissions

    The all-photochemical synthesis of an OGP(10–14) precursor

    J. Débieux and C. G. Bochet, Chem. Sci., 2012, 3, 405
    DOI: 10.1039/C1SC00700A

Search articles by author

Spotlight

Advertisements