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Issue 8, 2013
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Phospholipid micelle encapsulated gadolinium oxide nanoparticles for imaging and gene delivery

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Abstract

We encapsulated gadolinium oxide (Gd2O3) nanoparticles within phospholipid micelles as a novel low cytotoxic T1-weighted MRI imaging contrast agent (MGdNPs) that can also deliver small molecules such as DNA plasmids. MGdNPs show relatively good MRI relaxivity values, negligible cytotoxicity, excellent cellular uptake and expression of DNA plasmids in vivo. Biodistribution studies in mice show that intranasal and intraperitoneal administration of MGdNPs can effectively target specific organs.

Graphical abstract: Phospholipid micelle encapsulated gadolinium oxide nanoparticles for imaging and gene delivery

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Article information


Submitted
25 Sep 2012
Accepted
06 Dec 2012
First published
07 Dec 2012

RSC Adv., 2013,3, 2727-2735
Article type
Paper

Phospholipid micelle encapsulated gadolinium oxide nanoparticles for imaging and gene delivery

S. Dixit, M. Das, S. Alwarappan, N. L. Goicochea, M. Howell, S. Mohapatra and S. Mohapatra, RSC Adv., 2013, 3, 2727
DOI: 10.1039/C2RA22293K

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