Green and recyclable glycine nitrate (GlyNO3) ionic liquid triggered multicomponent Biginelli reaction for the efficient synthesis of dihydropyrimidinones

Abstract

Herein we report the use of an amino acid ionic liquid as a green catalyst for the multicomponent synthesis of 3,4-dihydropyrimidin-2(1H)-ones in excellent yields and short reaction time. The ionic liquid is inexpensive and biodegradable and can be reused for more than ten consecutive reactions. The potential of the protocol for gram scale synthesis adds to its practical applicability.