Issue 30, 2012
From the journal:

RSC Advances

The protein corona of dendrimers: PAMAM binds and activates complement proteins in human plasma in a generation dependent manner†

Anna Åkesson,a   Marité Cárdenas,a   Giuliano Elia,b   Marco P. Monopoli*bc  and  Kenneth A. Dawson*c  

* Corresponding authors

a Institute of Chemistry and Nano-Science Center, Copenhagen University, Copenhagen, Denmark

b Mass Spectrometry Resource, Conway Institute for Biomolecular and Biomedical Research, University College Dublin, Belfield, Dublin 4, Ireland

c Centre for BioNano Interactions, School of Chemistry and Chemical Biology and Conway Institute for Biomolecular and Biomedical Research, University College Dublin, Belfield, Dublin 4, Ireland
E-mail: kenneth.a.dawson@cbni.ucd.ie, marco.monopoli@cbni.ucd.ie

Abstract

Dendrimers are polymers with a strong role in nanomedicine. In the current work we have developed a platform for mapping out the biomolecule corona for polyamidoamine (PAMAM) dendrimers. Complement proteins including C3 and C4b were found for the high generation dendrimers, suggesting high affinities to the dendrimers and most importantly complement activation.

Graphical abstract: The protein corona of dendrimers: PAMAM binds and activates complement proteins in human plasma in a generation dependent manner

About
Cited by
Related
Download options Please wait...

Supplementary files

Article information

DOI
https://doi.org/10.1039/C2RA21866F
Article type
Communication
Submitted
18 Aug 2012
Accepted
16 Sep 2012
First published
21 Sep 2012

RSC Adv., 2012,2, 11245-11248

Permissions

Request permissions

The protein corona of dendrimers: PAMAM binds and activates complement proteins in human plasma in a generation dependent manner

A. Åkesson, M. Cárdenas, G. Elia, M. P. Monopoli and K. A. Dawson, RSC Adv., 2012, 2, 11245 DOI: 10.1039/C2RA21866F

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements