Issue 29, 2012
From the journal:

RSC Advances

Investigations of the structural evolution of electrospun nanofibers using atomic force microscopy†

Peng Xu,ab   Wei Li,*ac   Huacong Zhou,ab   Feng Pan,a   Huifang Xinga  and  Huizhou Liu*a  

* Corresponding authors

a State Key Laboratory of Biochemical Engineering, Key Laboratory of Green Process and Engineering, Institute of Process Engineering, Chinese Academy of Sciences, Beijing, China
E-mail: hzliu@home.ipe.ac.cn
Fax: +86-10-62554254
Tel: +86-10-62554264

b Graduate School of Chinese Academy of Science, Beijing, China
E-mail: qingkeer111@163.com
Fax: +86-10-62554254
Tel: +86-10-82544954

c Department of Chemistry, Capital Normal University, Beijing, China
E-mail: wli@cnu.ac.edu.cn
Fax: +86-10-68903086
Tel: +86-10-68903086

Abstract

Stepwise structural evolution of nanofibers through electrospinning was captured by AFM imaging. Nanofiber evolution exhibited five characteristic structures in turn: columns, plates, micropores, bumps and smooth surface. Based on our results and previous studies, these five stages are discussed in detail and the mechanism of nanofiber formation is proposed. In addition, the drug incorporation process of blend-electrospun nanofibers was shown vividly and clearly by AFM. It suggested that drugs could be completely incorporated into nanofibers by blend-electrospinning if proper polymers and drugs were chosen. Furthermore, the effects of solution properties on nanofiber structural evolution were also studied systematically.

Graphical abstract: Investigations of the structural evolution of electrospun nanofibers using atomic force microscopy

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Article information

DOI
https://doi.org/10.1039/C2RA20146A
Article type
Paper
Submitted
14 Nov 2011
Accepted
01 Aug 2012
First published
06 Aug 2012

RSC Adv., 2012,2, 11104-11110

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Investigations of the structural evolution of electrospun nanofibers using atomic force microscopy

P. Xu, W. Li, H. Zhou, F. Pan, H. Xing and H. Liu, RSC Adv., 2012, 2, 11104 DOI: 10.1039/C2RA20146A

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