Issue 7, 2012

Exploiting the use of ionic liquids to access phosphorodiamidites

Abstract

A series of phosphorodiamidite reagents have been readily prepared using bis{(trifluoromethyl)sulfonyl}imide based ionic liquids and compared with their syntheses in conventional organic solvents. This method demonstrates a versatile procedure that allows access to both known and novel phosphorodiamidite reagents, whilst addressing issues such as moisture sensitivity and product selectivity present in current molecular based protocols. This method negates the need for reagent purification, whilst allowing for the reactions to be conducted at high concentrations.

Graphical abstract: Exploiting the use of ionic liquids to access phosphorodiamidites

Supplementary files

Article information

Article type
Paper
Submitted
23 Jan 2012
Accepted
23 Jan 2012
First published
25 Jan 2012

RSC Adv., 2012,2, 2988-2993

Exploiting the use of ionic liquids to access phosphorodiamidites

K. Crossey, C. Hardacre, M. E. Migaud and S. E. Norman, RSC Adv., 2012, 2, 2988 DOI: 10.1039/C2RA20131C

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