Issue 8, 2012
From the journal:

RSC Advances

Iodine catalyzed four-component reaction: a straightforward one-pot synthesis of functionalized pyrroles under metal-free conditions†

G. Rajeshwar Reddy,ab   T. Ram Reddy,a   Suju C. Joseph,a   K. Sateesh Reddya  and  Manojit Pal*c  

* Corresponding authors

a Custom Pharmaceutical Services, Dr Reddy's Laboratories Limited, Bollaram Road Miyapur, Hyderabad, India

b Chemistry Division, Institute of Science and Technology, JNT University, Kukatpally, Hyderabad, Andhra Pradesh, India

c Institute of Life Sciences, University of Hyderabad Campus, Gachibowli, Hyderabad, India
E-mail: manojitpal@rediffmail.com

Abstract

An iodine-catalyzed four-component reaction of 1,3-dicarbonyl compounds, amines, aldehydes and nitroalkanes afforded polysubstituted pyrroles under a metal free condition. Simplicity, low cost and good yields are the key features of this methodology. The mechanism of this four component process is discussed and structural elaboration of one of the compounds synthesized using Suzuki and Sonogashira coupling is presented.

Graphical abstract: Iodine catalyzed four-component reaction: a straightforward one-pot synthesis of functionalized pyrroles under metal-free conditions

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Article information

DOI
https://doi.org/10.1039/C2RA00982J
Article type
Paper
Submitted
30 Oct 2011
Accepted
22 Dec 2011
First published
28 Feb 2012

RSC Adv., 2012,2, 3387-3395

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Iodine catalyzed four-component reaction: a straightforward one-pot synthesis of functionalized pyrroles under metal-free conditions

G. R. Reddy, T. R. Reddy, S. C. Joseph, K. S. Reddy and M. Pal, RSC Adv., 2012, 2, 3387 DOI: 10.1039/C2RA00982J

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