Poly(tris(hydroxymethyl)acrylamidomethane)-based copolymers: a new class of acid-labile thermosensitive polymers

The present contribution reports on an original new class of acid-labile thermosensitive polyacrylamides, namely poly(tris(hydroxymethyl)acrylamidomethane-co-(5-acrylamido-5-hydroxymethyl-2,2-dimethyl-1,3-dioxane)) (P(THAM-co-pTHAM)), in which pTHAM only differed from THAM by an acetal group. The lower critical solution temperature (LCST) was controlled by varying the comonomer composition. Additionally, the properties of these new statistical copolymers were investigated and proved that such chemical structures were interesting for smart applications, notably for drug delivery due to the biocompatibility of low molecular weight PTHAM already demonstrated.