Issue 8, 2012
From the journal:

Photochemical & Photobiological Sciences

β-Cyclodextrin polymernanoparticles as carriers for doxorubicin and artemisinin: a spectroscopic and photophysical study†

Resmi Anand,a   Francesco Manoli,a   Ilse Manet,a   Samia Daoud-Mahammed,b   Valentina Agostoni,b   Ruxandra Grefb  and  Sandra Monti*a  

* Corresponding authors

a Istituto per la Sintesi Organica e la Fotoreattività, ISOF-CNR, via P. Gobetti 101, 40129 Bologna, Italy
E-mail: monti@isof.cnr.it
Tel: +390516399813

b Université Paris-Sud, UMR CNRS 8612, 92296 Chatenay Malabry, France

Abstract

The association of doxorubicin (DOX) and artemisinin (ART) to a β-CyD-epichlorohydrin crosslinked polymer (pβ-CyD), organized in nanoparticles of ca. 15 nm size, was investigated in neutral aqueous medium by circular dichroism (CD), UV-vis absorption and fluorescence. The stability constants and the absolute CD spectra of the drug complexes were determined by global analysis of multiwavelength data from spectroscopic titrations. The polymer pβ-CyD proved able to disrupt the DOX dimer when the latter is the predominant form of DOX in solution. The spectroscopic and photophysical properties of the complexes evidenced an alcohol-like environment for ART and an improved inherent emission ability for DOX in the nanoparticle frame.

Graphical abstract: β-Cyclodextrin polymer nanoparticles as carriers for doxorubicin and artemisinin: a spectroscopic and photophysical study

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Article information

DOI
https://doi.org/10.1039/C2PP25014D
Article type
Paper
Submitted
20 Jan 2012
Accepted
02 Apr 2012
First published
11 May 2012

Photochem. Photobiol. Sci., 2012,11, 1285-1292

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β-Cyclodextrin polymer nanoparticles as carriers for doxorubicin and artemisinin: a spectroscopic and photophysical study

R. Anand, F. Manoli, I. Manet, S. Daoud-Mahammed, V. Agostoni, R. Gref and S. Monti, Photochem. Photobiol. Sci., 2012, 11, 1285 DOI: 10.1039/C2PP25014D

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