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Issue 8, 2013
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Cu-catalyzed direct C–H bond functionalization: a regioselective protocol to 5-aryl thiazolo[3,2-b]-1,2,4-triazoles

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Abstract

An efficient, regioselective C-5 arylation of thiazolo[3,2-b]-1,2,4-triazoles catalyzed by a simple copper catalyst was developed. This arylation proceeded smoothly and tolerated a variety of functional groups (44 examples). A wide range of functionalized thiazolo[3,2-b]-1,2,4-triazole derivatives were obtained in high yields (up to 99% yield). Possible catalytic cycles of the arylation were also discussed.

Graphical abstract: Cu-catalyzed direct C–H bond functionalization: a regioselective protocol to 5-aryl thiazolo[3,2-b]-1,2,4-triazoles

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Article information


Submitted
10 Oct 2012
Accepted
03 Dec 2012
First published
12 Dec 2012

Org. Biomol. Chem., 2013,11, 1390-1398
Article type
Paper

Cu-catalyzed direct C–H bond functionalization: a regioselective protocol to 5-aryl thiazolo[3,2-b]-1,2,4-triazoles

Z. Xie, X. Zhu, Y. Guan, D. Zhu, H. Hu, C. Lin, Y. Pan, J. Jiang and L. Wang, Org. Biomol. Chem., 2013, 11, 1390
DOI: 10.1039/C2OB27326H

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