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Issue 44, 2012
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Construction of ratiometric fluorescent sensors by ribonucleopeptides

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Abstract

Ratiometric fluorescent sensors were constructed from RNA aptamers by generating modular ribonucleopeptide complexes. Fluorescent ribonucleopeptides containing fluorophore seminaphthorhodafluor tethered to their peptide subunit revealed a dual emission property, which permitted a ratiometric fluorescent measurement of a substrate-binding event. The strategy successfully afforded ratiometric fluorescent sensors for biologically active small ligands, tetracycline, dopamine and streptomycin.

Graphical abstract: Construction of ratiometric fluorescent sensors by ribonucleopeptides

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Supplementary files

Article information


Submitted
31 Aug 2012
Accepted
04 Oct 2012
First published
04 Oct 2012

Org. Biomol. Chem., 2012,10, 8767-8769
Article type
Communication

Construction of ratiometric fluorescent sensors by ribonucleopeptides

C. Annoni, E. Nakata, T. Tamura, F. F. Liew, S. Nakano, M. L. Gelmi and T. Morii, Org. Biomol. Chem., 2012, 10, 8767
DOI: 10.1039/C2OB26722E

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