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Issue 44, 2012
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Construction of ratiometric fluorescent sensors by ribonucleopeptides

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Abstract

Ratiometric fluorescent sensors were constructed from RNA aptamers by generating modular ribonucleopeptide complexes. Fluorescent ribonucleopeptides containing fluorophore seminaphthorhodafluor tethered to their peptide subunit revealed a dual emission property, which permitted a ratiometric fluorescent measurement of a substrate-binding event. The strategy successfully afforded ratiometric fluorescent sensors for biologically active small ligands, tetracycline, dopamine and streptomycin.

Graphical abstract: Construction of ratiometric fluorescent sensors by ribonucleopeptides

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Publication details

The article was received on 31 Aug 2012, accepted on 04 Oct 2012 and first published on 04 Oct 2012


Article type: Communication
DOI: 10.1039/C2OB26722E
Org. Biomol. Chem., 2012,10, 8767-8769

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    Construction of ratiometric fluorescent sensors by ribonucleopeptides

    C. Annoni, E. Nakata, T. Tamura, F. F. Liew, S. Nakano, M. L. Gelmi and T. Morii, Org. Biomol. Chem., 2012, 10, 8767
    DOI: 10.1039/C2OB26722E

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