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Issue 48, 2012
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Synthesis and duplex-forming ability of oligonucleotides containing 4′-carboxythymidine analogs

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Abstract

Oligonucleotides containing 4′-carboxy-, 4′-methoxycarbonyl-, 4′-carbamoyl-, and 4′-methylcarbamoyl-thymidines, and their 2′-methoxy, 2′-amino or 2′-acetamido analogs were prepared. Their duplex-forming ability with DNA and RNA complements was evaluated by UV melting experiments. Interestingly, 4′-carboxythymidine existing in the S-type sugar conformation was found to lead to an increase in the stability of the duplex formed with RNA complements compared to natural thymidine.

Graphical abstract: Synthesis and duplex-forming ability of oligonucleotides containing 4′-carboxythymidine analogs

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Publication details

The article was received on 30 Aug 2012, accepted on 23 Oct 2012 and first published on 08 Nov 2012


Article type: Paper
DOI: 10.1039/C2OB26712H
Org. Biomol. Chem., 2012,10, 9639-9649

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    Synthesis and duplex-forming ability of oligonucleotides containing 4′-carboxythymidine analogs

    Y. Hari, T. Osawa and S. Obika, Org. Biomol. Chem., 2012, 10, 9639
    DOI: 10.1039/C2OB26712H

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