Brønsted acid promoted benzylic C–H bond functionalization of azaarenes: nucleophilic addition to aldehydes

Abstract

A practical Brønsted acid promoted benzylic C–H functionalization of 2-methylazaarenes and nucleophilic addition to aldehydes was developed in good to excellent yields. A six-membered hydrogen-bonding transition state is proposed to be crucial for the reaction. Ready availability of the two starting materials, the use of acetic acid as the catalyst and the facile reaction conditions will guarantee this synthetic method attractive to the synthesis of bioactive pyridine and quinoline derivatives.