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Issue 43, 2012
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1,8-Naphthyridine-2,7-diamine: a potential universal reader of Watson–Crick base pairs for DNA sequencing by electron tunneling

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Abstract

With the aid of Density Functional Theory (DFT), we designed 1,8-naphthyridine-2,7-diamine as a recognition molecule to read DNA base pairs for genomic sequencing by electron tunneling. NMR studies show that it can form stable triplets with both A : T and G : C base pairs through hydrogen bonding. Our results suggest that the naphthyridine molecule should be able to function as a universal base pair reader in a tunneling gap, generating distinguishable signatures under electrical bias for each of DNA base pairs.

Graphical abstract: 1,8-Naphthyridine-2,7-diamine: a potential universal reader of Watson–Crick base pairs for DNA sequencing by electron tunneling

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Article information


Submitted
02 Aug 2012
Accepted
13 Sep 2012
First published
13 Sep 2012

Org. Biomol. Chem., 2012,10, 8654-8659
Article type
Paper

1,8-Naphthyridine-2,7-diamine: a potential universal reader of Watson–Crick base pairs for DNA sequencing by electron tunneling

F. Liang, S. Lindsay and P. Zhang, Org. Biomol. Chem., 2012, 10, 8654
DOI: 10.1039/C2OB26529J

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