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Issue 40, 2012

Highly enantioselective synthesis of Warfarin and its analogs catalysed by primary amine–phosphinamide bifunctional catalysts

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Abstract

An efficient enantioselective Michael addition of 4-hydroxycoumarin to α,β-unsaturated ketones catalysed by primary aminephosphinamide bifunctional catalysts has been developed. This reaction afforded Warfarin and its analogs in moderate to excellent yields (up to 99%) and good to excellent enantioselectivities (up to 99% ee).

Graphical abstract: Highly enantioselective synthesis of Warfarin and its analogs catalysed by primary amine–phosphinamide bifunctional catalysts

Supplementary files

Article information


Submitted
12 Jul 2012
Accepted
24 Aug 2012
First published
28 Aug 2012

Org. Biomol. Chem., 2012,10, 8125-8131
Article type
Paper

Highly enantioselective synthesis of Warfarin and its analogs catalysed by primary aminephosphinamide bifunctional catalysts

J. Dong and D. Du, Org. Biomol. Chem., 2012, 10, 8125 DOI: 10.1039/C2OB26334C

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