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A naphthalimide–rhodamine B derivative was synthesized as a fluorescence turn-ON chemodosimeter for Sn4+. A colour change and marked enhancement of fluorescence was found in the presence of Sn4+, Cu2+ and Cr3+ due to the ring open reaction of rhodamine and a fluorescence resonance energy transfer process. Addition of the strong chelating agent ethylenediaminetetraacetic acid disodium salt (EDTA) partly released the cation from the complex with Sn4+ and restored the yellow fluorescence. In addition, the compound can be used as a fluorescent probe for Sn4+ in biological systems and may act as a tool with which to study the physiological functions of tin or pathogenesis in the human body.

Graphical abstract: A highly selective fluorescence sensor for Tin (Sn4+) and its application in imaging live cells

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