A multicomponent synthetic strategy for two-carbon-tethered 1,3-oxathiole–indole pairs

An efficient methodology for the multicomponent synthesis of new and highly functionalized heterocycles containing 1,3-oxathiole and indole units which are connected through an sp²-C₂ bridge has been developed. This domino reaction enables successful assembly of three new sigma bonds including a C–S bond and a C–O bond in a one-pot operation. Features of this strategy include mild conditions, convenient one-pot operation, and high stereo- and regioselectivity.