A rapid and efficient protocol to afford the title compound 2-[18F]-fluoro-2,2-difluoroethyl tosylate ([18F]7b) is described. Starting from [18F]fluoride ion, labelling reagent 7b was obtained in good yields and a high specific radioactivity. Compound ([18F]7b) was then used to synthesise a prospective radiotracer for PET-imaging in dementia.
![Graphical abstract: Direct, nucleophilic radiosynthesis of [18F]trifluoroalkyl tosylates: improved labelling procedures](/en/Image/Get?imageInfo.ImageType=GA&imageInfo.ImageIdentifier.ManuscriptID=C2OB25802A&imageInfo.ImageIdentifier.Year=2012)
P. J. Riss, V. Ferrari, L. Brichard, P. Burke, R. Smith and F. I. Aigbirhio, Org. Biomol. Chem., 2012, 10, 6980 DOI: 10.1039/C2OB25802A
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