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Abstract | Cited by

An efficient and general method for the synthesis of unsymmetrical tetrasubstituted ureas from carbamoylimidazole is described. The conversion is achieved by the concurrent quarternization of the imidazole nitrogen and activation of amines with AlMe3.

Graphical abstract: Unsymmetrical tetrasubstituted ureas from tertiary carbamoylimidazole: activation by AlMe3

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