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Issue 19, 2012

A highly enantioselective approach towards 2-substituted 3-bromopyrrolidines

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Abstract

A facile and highly enantioselective approach towards 2-substituted 3-bromopyrrolidines has been developed. The process involves an amino-thiocarbamate catalyzed bromoaminocyclization of 1,2-disubstituted olefinic amides. The pyrrolidine products could readily be converted into other useful building blocks including a dihydropyrrole and a 2-substituted pyrrolidine.

Graphical abstract: A highly enantioselective approach towards 2-substituted 3-bromopyrrolidines

Supplementary files

Article information


Submitted
14 Feb 2012
Accepted
06 Mar 2012
First published
07 Mar 2012

Org. Biomol. Chem., 2012,10, 3808-3811
Article type
Communication

A highly enantioselective approach towards 2-substituted 3-bromopyrrolidines

J. Chen, L. Zhou and Y. Yeung, Org. Biomol. Chem., 2012, 10, 3808 DOI: 10.1039/C2OB25327E

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