Issue 17, 2012
From the journal:

Organic & Biomolecular Chemistry

A convenient and mild chromatography-free method for the purification of the products of Wittig and Appel reactions†

Peter A. Byrne,a   Kamalraj V. Rajendran,a   Jimmy Muldoona  and  Declan G. Gilheany*a  

* Corresponding authors

a Centre for Synthesis and Chemical Biology, School of Chemistry and Chemical Biology, University College Dublin, Belfield, Dublin 4, Ireland
E-mail: declan.gilheany@ucd.ie
Fax: +353-1-7162127
Tel: +353-1-7162308

Abstract

A mild method for the facile removal of phosphine oxide from the crude products of Wittig and Appel reactions is described. Work-up with oxalyl chloride to generate insoluble chlorophosphonium salt (CPS) yields phosphorus-free products for a wide variety of these reactions. The CPS product can be further converted into phosphine.

Graphical abstract: A convenient and mild chromatography-free method for the purification of the products of Wittig and Appel reactions

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Article information

DOI
https://doi.org/10.1039/C2OB07074J
Article type
Paper
Submitted
12 Dec 2011
Accepted
05 Mar 2012
First published
05 Mar 2012

Org. Biomol. Chem., 2012,10, 3531-3537

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A convenient and mild chromatography-free method for the purification of the products of Wittig and Appel reactions

P. A. Byrne, K. V. Rajendran, J. Muldoon and D. G. Gilheany, Org. Biomol. Chem., 2012, 10, 3531 DOI: 10.1039/C2OB07074J

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