Jump to main content
Jump to site search

Issue 17, 2012
Previous Article Next Article

A convenient and mild chromatography-free method for the purification of the products of Wittig and Appel reactions

Author affiliations

Abstract

A mild method for the facile removal of phosphine oxide from the crude products of Wittig and Appel reactions is described. Work-up with oxalyl chloride to generate insoluble chlorophosphonium salt (CPS) yields phosphorus-free products for a wide variety of these reactions. The CPS product can be further converted into phosphine.

Graphical abstract: A convenient and mild chromatography-free method for the purification of the products of Wittig and Appel reactions

Back to tab navigation

Supplementary files

Article information


Submitted
12 Dec 2011
Accepted
05 Mar 2012
First published
05 Mar 2012

Org. Biomol. Chem., 2012,10, 3531-3537
Article type
Paper

A convenient and mild chromatography-free method for the purification of the products of Wittig and Appel reactions

P. A. Byrne, K. V. Rajendran, J. Muldoon and D. G. Gilheany, Org. Biomol. Chem., 2012, 10, 3531
DOI: 10.1039/C2OB07074J

Social activity

Search articles by author

Spotlight

Advertisements