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Issue 11, 2012

Highly efficient asymmetric aldol reaction in brine using a fluorous sulfonamide organocatalyst

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Abstract

A fluorous organocatalyst promotes direct asymmetric aldol reactions of aromatic aldehydes with ketones in brine to afford the corresponding anti-aldol products in high yield with up to 96% ee. Fluorous organocatalyst can be readily recovered by solid phase extraction using fluorous silica gel and reused without purification.

Graphical abstract: Highly efficient asymmetric aldol reaction in brine using a fluorous sulfonamide organocatalyst

Supplementary files

Article information


Submitted
22 Nov 2011
Accepted
06 Jan 2012
First published
09 Jan 2012

Org. Biomol. Chem., 2012,10, 2209-2213
Article type
Communication

Highly efficient asymmetric aldol reaction in brine using a fluorous sulfonamide organocatalyst

T. Miura, H. Kasuga, K. Imai, M. Ina, N. Tada, N. Imai and A. Itoh, Org. Biomol. Chem., 2012, 10, 2209 DOI: 10.1039/C2OB06955E

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