Issue 8, 2012
From the journal:

Organic & Biomolecular Chemistry

A new and convenient approach for the preparation of β-cyanoethyl protected trinucleotidephosphoramidites†

Matthäus Janczyk,ab   Bettina Appel,a   Danilo Springstubbe,a   Hans-Joachim Fritzc  and  Sabine Müller*a  

* Corresponding authors

a Ernst-Moritz-Arndt-Universität Greifswald, Institut für Biochemie, Felix-Hausdorff-Str., 4, Greifswald, Germany
E-mail: smueller@uni-greifswald.de
Fax: +49 3834 864471
Tel: +49 3834 8622843

b present address: Laborbetriebsgesellschaft Dr Dirkes-Kersting und Dr Kirchner mbH, Rotthauser Str. 19, Gelsenkirchen, Germany

c Georg-August Universität Göttingen, Institut für Mikrobiologie und Genetik, Grisebachstr., 8, Göttingen, Germany

Abstract

Herein we report a convenient approach for the preparation of fully protected trinucleotide synthons to be used for the synthesis of gene libraries. The trinucleotide synthons bear β-cyanoethyl groups at the phosphate residues, and thus can be used in standard oligonucleotide synthesis without additional steps for deprotection and work-up.

Graphical abstract: A new and convenient approach for the preparation of β-cyanoethyl protected trinucleotide phosphoramidites

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Article information

DOI
https://doi.org/10.1039/C2OB06934B
Article type
Communication
Submitted
17 Nov 2011
Accepted
14 Dec 2011
First published
19 Dec 2011

Org. Biomol. Chem., 2012,10, 1510-1513

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A new and convenient approach for the preparation of β-cyanoethyl protected trinucleotide phosphoramidites

M. Janczyk, B. Appel, D. Springstubbe, H. Fritz and S. Müller, Org. Biomol. Chem., 2012, 10, 1510 DOI: 10.1039/C2OB06934B

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