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Abstract | Cited by

Herein we report a convenient approach for the preparation of fully protected trinucleotide synthons to be used for the synthesis of gene libraries. The trinucleotide synthons bear β-cyanoethyl groups at the phosphate residues, and thus can be used in standard oligonucleotide synthesis without additional steps for deprotection and work-up.

Graphical abstract: A new and convenient approach for the preparation of β-cyanoethyl protected trinucleotide phosphoramidites

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