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Issue 10, 2012
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Formation of new base pairs between inosine and 5-methyl-2-thiocytidine derivatives

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Abstract

In this paper, we report DNA and 2′-OMe-RNA probes containing 5-methyl-2-thiocytidine (m5s2C) residues that can bind selectively and strongly to the corresponding RNA targets containing inosine residues by the significant stacking effect and steric hindrance of the 2-thiocarbonyl group.

Graphical abstract: Formation of new base pairs between inosine and 5-methyl-2-thiocytidine derivatives

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Article information


Submitted
27 Sep 2011
Accepted
06 Dec 2011
First published
07 Dec 2011

Org. Biomol. Chem., 2012,10, 2008-2010
Article type
Paper

Formation of new base pairs between inosine and 5-methyl-2-thiocytidine derivatives

A. Ohkubo, Y. Nishino, Y. Ito, H. Tsunoda, K. Seio and M. Sekine, Org. Biomol. Chem., 2012, 10, 2008
DOI: 10.1039/C2OB06641F

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