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Issue 1, 2012
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A concise asymmetric synthesis of (−)-rasfonin

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Abstract

A very efficient total synthesis of the apoptosis inducer (−)-rasfonin has been developed using CuBr/JosiPhos catalyzed iterative asymmetric conjugate addition of MeMgBr and Feringa's butenolide.

Graphical abstract: A concise asymmetric synthesis of (−)-rasfonin

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Supplementary files

Article information


Submitted
07 Oct 2011
Accepted
25 Oct 2011
First published
24 Nov 2011

Org. Biomol. Chem., 2012,10, 29-31
Article type
Communication

A concise asymmetric synthesis of (−)-rasfonin

Y. Huang, A. J. Minnaard and B. L. Feringa, Org. Biomol. Chem., 2012, 10, 29
DOI: 10.1039/C1OB06700A

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